The incident happened around 8:30 a.m. Tuesday on Avenue J at 70th Street East, according to a California Highway Patrol report.
Jacqueline Gonzalez, 24, of Lancaster was driving a 1993 Toyota Previa northbound on 70th Street East and had come to a complete stop at the posted stop sign at the Avenue J intersection, according to the CHP report.
The second vehicle, a 2010 Toyota Camry driven by 49-year-old Bronwynne Morris of Victorville, was traveling westbound on Avenue J at about 55 to 60 miles per hour, according to the report.
Gonzalez failed to clear the roadway from oncoming traffic and drove the minivan directly into the path of the Camry, and as a result, both vehicles collided, the CHP report states.
The Camry then struck a wooden telephone pole, breaking it from the base. Morris suffered moderate injuries, including pain to the neck and back, and was transported to Antelope Valley Hospital.
Gonzalez suffered major injuries, including facial injuries and pain to the body, and was transported to Antelope Valley Hospital.
An adult passenger in the minivan, 24-year-old Angel F. Aguilar of Lancaster, also suffered major injuries and was transported to Antelope Valley Hospital.
All five children riding in the minivan were transported by ambulance to Antelope Valley Hospital for evaluation.
A 9-year-old boy sustained a laceration to the left eye, and a 5-year-old boy sustained lacerations to the forehead.
A 1-year-old boy, a 3-year-old girl, and a 7-year-old girl were not injured in the collision, according to the CHP report.
During the preliminary investigation, it was determined that three out of the five children riding in the minivan were not properly secured in a child passenger safety restraint system, according to CHP Officer P. Torres.
The traffic collision is still under investigation, and DUI is not suspected to be a factor in the collision.