No major injuries were reported, according to deputies at the scene.
The incident occurred around 2:45 p.m. in the westbound lanes of Palmdale Boulevard, between 25th and 22nd Street East.
Among the vehicles stopped were a Nissan Altima, a blue Ford Focus and a white Saturn.
A Ford F150 pick-up truck towing a horse trailer approached the scene at a high rate of speed and did not brake for the stopped vehicles, according to witnesses.
The Ford pick-up truck slammed into the back of the Ford Focus, sending it into the back of the Nissan Altima, sending the Altima into the back of the Saturn, and sending the Saturn into the back of the U-haul trailer.
The Focus ended up sandwiched between the Ford pick-up and the Altima, and its female driver had to be extricated from the vehicle. She was transported to the hospital with minor bruises.
Deputies on the scene conducted a field sobriety test with the Ford pick-up truck’s driver, which proved inconclusive.
He was detained and taken to Palmdale Regional Medical Center for further blood tests.
The investigation is ongoing. Information is preliminary and could change with further investigation, according to deputies at the scene.
* Story updated. The Ford Focus driver was extricated from the vehicle. At least two people were transported to the hospital.